3.0M
XNAS Volume
High volume+loss today
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Sushil Patel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 12.42 per share. | 16 Dec 2024 | 10,000 | 202,014 (0%) | 0% | 12.4 | 124,200 | Common Stock |
| Konstantinos Xynos | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 10.78 per share. | 18 Nov 2024 | 7,246 | 109,885 (0%) | 0% | 10.8 | 78,112 | Common Stock |
| Christopher Sarchi | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 10.78 per share. | 18 Nov 2024 | 5,207 | 87,045 (0%) | 0% | 10.8 | 56,131 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Aug 2024 | 50,000 | 1,437,350 (3%) | 0% | 0 | Common Stock | |
| Emily Hill | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.18 per share. | 16 Aug 2024 | 8,938 | 101,057 (0%) | 0% | 10.2 | 90,989 | Common Stock |
| Konstantinos Xynos | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.50 per share. | 07 Jun 2024 | 15,881 | 117,131 (0%) | 0% | 7.5 | 119,108 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 37,928 | 1,487,350 (4%) | 0% | 6.5 | 245,394 | Common Stock |
| Robert Coffin | Director | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 11,464 | 1,821,872 (4%) | 0% | 6.5 | 74,172 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 17,615 | 777,345 (2%) | 0% | 6.5 | 113,969 | Common Stock |
| Sushil Patel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 20,194 | 212,014 (0%) | 0% | 6.5 | 130,655 | Common Stock |
| Konstantinos Xynos | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 6,367 | 133,012 (0%) | 0% | 6.5 | 41,194 | Common Stock |
| Andrew Schwendenman | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 2,298 | 38,238 (0%) | 0% | 6.5 | 14,868 | Common Stock |
| Christopher Sarchi | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 6.47 per share. | 16 May 2024 | 2,218 | 92,252 (0%) | 0% | 6.5 | 14,350 | Common Stock |
| Hyam I. Levitsky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Paolo Pucci | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Kapil Dhingra | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Dieter Weinand | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Emily Hill | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| Emily Hill | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 26,665 | 109,995 (0%) | 0% | 0 | Common Stock | |
| Christy J. Oliger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Sushil Patel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 83,335 | 232,208 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 250,000 | 250,000 | - | - | Employee Stock Option (right to buy) | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 26,665 | 139,379 (0%) | 0% | 0 | Common Stock | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 80,000 | 80,000 | - | - | Employee Stock Option (right to buy) | |
| Andrew Schwendenman | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 53,325 | 53,325 | - | - | Employee Stock Option (right to buy) | |
| Andrew Schwendenman | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 17,775 | 40,536 (0%) | 0% | 0 | Common Stock | |
| Veleka Peeples-Dyer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Christopher Sarchi | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 66,675 | 66,675 | - | - | Employee Stock Option (right to buy) | |
| Christopher Sarchi | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2024 | 22,225 | 94,470 (0%) | 0% | 0 | Common Stock | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 22 Aug 2023 | 13,600 | 277,036 (0%) | 0% | 3.3 | 44,880 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Aug 2023 | 5,000 | 35,750 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Aug 2023 | 13,600 | 91,691 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 22 Aug 2023 | 18,600 | 263,436 (0%) | 0% | 20.0 | 372,186 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.50 per share. | 22 Aug 2023 | 5,000 | 282,036 (0%) | 0% | 15.5 | 77,500 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 11 Aug 2023 | 1,400 | 263,436 (0%) | 0% | 20 | 28,000 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2023 | 1,400 | 105,291 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 11 Aug 2023 | 1,400 | 264,836 (0%) | 0% | 3.3 | 4,620 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.50 per share. | 10 Jul 2023 | 5,000 | 283,436 (0%) | 0% | 15.5 | 77,500 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2023 | 5,000 | 40,750 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2023 | 15,000 | 106,691 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 21.12 per share. | 10 Jul 2023 | 2,077 | 263,436 (0%) | 0% | 21.1 | 43,866 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 21.63 per share. | 10 Jul 2023 | 17,923 | 265,513 (0%) | 0% | 21.6 | 387,674 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 10 Jul 2023 | 15,000 | 278,436 (0%) | 0% | 3.3 | 49,500 | Common Stock |
| Tanya Lewis | Chief Dev. Op. Officer | Sale of securities on an exchange or to another person at price $ 24.10 per share. | 13 Jun 2023 | 12,043 | 136,110 (0%) | 0% | 24.1 | 290,236 | Common Stock |
| Tanya Lewis | Chief Dev. Op. Officer | Sale of securities on an exchange or to another person at price $ 23.45 per share. | 13 Jun 2023 | 817 | 135,293 (0%) | 0% | 23.5 | 19,159 | Common Stock |
| Sushil Patel | Chief Strategy Officer | Sale of securities on an exchange or to another person at price $ 24.11 per share. | 13 Jun 2023 | 5,145 | 149,426 (0%) | 0% | 24.1 | 124,046 | Common Stock |
| Sushil Patel | Chief Strategy Officer | Sale of securities on an exchange or to another person at price $ 23.44 per share. | 13 Jun 2023 | 553 | 148,873 (0%) | 0% | 23.4 | 12,962 | Common Stock |
| Veleka Peeples-Dyer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 50,400 | 50,400 | - | - | Employee Stock Option (right to buy) | |
| Tanya Lewis | Chief Dev. Op. Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 12,207 | 148,153 (0%) | 0% | 18.0 | 220,336 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 17,902 | 1,525,278 (4%) | 0% | 18.0 | 323,131 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 11,351 | 128,748 (0%) | 0% | 18.1 | 204,886 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 5,966 | 263,436 (0%) | 0% | 18.0 | 107,686 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 7,861 | 1,833,336 (5%) | 0% | 18.0 | 141,891 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 10,775 | 794,960 (2%) | 0% | 18.1 | 194,489 | Common Stock |
| Sushil Patel | Chief Strategy Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 15,575 | 154,571 (0%) | 0% | 18.1 | 281,129 | Common Stock |
| Konstantinos Xynos | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 16 May 2023 | 771 | 120,027 (0%) | 0% | 18.1 | 13,917 | Common Stock |
| Hyam I. Levitsky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Paolo Pucci | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Tanya Lewis | Chief Dev. Op. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 40,000 | 160,360 (0%) | 0% | 0 | Common Stock | |
| Tanya Lewis | Chief Dev. Op. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Kapil Dhingra | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 213,150 | 213,150 | - | - | Employee Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 142,100 | 1,543,180 (4%) | 0% | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 45,000 | 140,099 (0%) | 0% | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 67,500 | 67,500 | - | - | Employee Stock Option (right to buy) | |
| Dieter Weinand | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 37,800 | 37,800 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 40,000 | 269,402 (0%) | 0% | 0 | Common Stock | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 67,500 | 67,500 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 45,000 | 1,841,197 (5%) | 0% | 0 | Common Stock | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 40,000 | 805,735 (2%) | 0% | 0 | Common Stock | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Christy J. Oliger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 25,200 | 25,200 | - | - | Stock Option (right to buy) | |
| Sushil Patel | Chief Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 40,000 | 170,146 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Chief Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 50,000 | 120,798 (0%) | 0% | 0 | Common Stock | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2023 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 09 Dec 2022 | 15,000 | 229,402 (0%) | 0% | 25.0 | 375,450 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 09 Dec 2022 | 15,000 | 244,402 (0%) | 0% | 1.0 | 15,150 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Dec 2022 | 15,000 | 36,203 | - | - | Employee Stock Option (right to buy) | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2022 | 26,250 | 26,250 | - | - | Employee Stock Option (right to buy) | |
| Konstantinos Xynos | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2022 | 17,500 | 70,798 (0%) | 0% | 0 | Common Stock | |
| Tanya Lewis | Chief Dev. Op Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 5,473 | 120,360 (0%) | 0% | 14.6 | 79,851 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 9,632 | 1,401,080 (3%) | 0% | 14.6 | 140,531 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 3,436 | 95,099 (0%) | 0% | 14.6 | 50,131 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 3,507 | 229,402 (0%) | 0% | 14.6 | 51,167 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 5,737 | 1,796,197 (4%) | 0% | 14.6 | 83,703 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 6,324 | 765,735 (2%) | 0% | 14.6 | 92,267 | Common Stock |
| Sushil Patel | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 14.59 per share. | 16 May 2022 | 10,687 | 130,146 (0%) | 0% | 14.6 | 155,923 | Common Stock |
| Hyam I. Levitsky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Paolo Pucci | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Tanya Lewis | Chief Dev.Op Off | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 78,750 | 78,750 | - | - | Employee Stock Option (right to buy) | |
| Tanya Lewis | Chief Dev.Op Off | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 52,500 | 125,833 (0%) | 0% | 0 | Common Stock | |
| Kapil Dhingra | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 105,000 | 105,000 | - | - | Employee Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 70,000 | 1,410,712 (3%) | 0% | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 78,750 | 78,750 | - | - | Employee Stock Option (right to buy) | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 52,500 | 98,535 (0%) | 0% | 0 | Common Stock | |
| Dieter Weinand | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 24,750 | 24,750 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 34,125 | 34,125 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 22,750 | 232,909 (0%) | 0% | 0 | Common Stock | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 26,250 | 1,801,934 (4%) | 0% | 0 | Common Stock | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 39,375 | 39,375 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 39,375 | 39,375 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 26,250 | 772,059 (2%) | 0% | 0 | Common Stock | |
| Christy J. Oliger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Sushil Patel | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 52,500 | 140,833 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 78,750 | 78,750 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.58 per share. | 15 Oct 2021 | 12,711 | 745,809 (2%) | 0% | 29.6 | 375,991 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.31 per share. | 15 Oct 2021 | 15,089 | 758,520 (2%) | 0% | 30.3 | 457,348 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.16 per share. | 15 Oct 2021 | 2,200 | 773,609 (2%) | 0% | 31.2 | 68,552 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.27 per share. | 16 Aug 2021 | 2,700 | 805,809 (2%) | 0% | 29.3 | 79,029 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 16 Aug 2021 | 27,300 | 808,509 (2%) | 0% | 30 | 819,000 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 20 Jul 2021 | 4,862 | 215,021 (0%) | 0% | 1.0 | 4,911 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 33.05 per share. | 20 Jul 2021 | 4,862 | 210,159 (0%) | 0% | 33.0 | 160,689 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 12,538 | 51,203 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 4,862 | 63,741 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 33.17 per share. | 20 Jul 2021 | 12,538 | 210,159 (0%) | 0% | 33.2 | 415,885 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 20 Jul 2021 | 12,538 | 222,697 (0%) | 0% | 1.0 | 12,663 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 15 Jul 2021 | 4,600 | 214,759 (0%) | 0% | 1.0 | 4,646 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2021 | 4,600 | 68,603 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 33.37 per share. | 15 Jul 2021 | 4,600 | 210,159 (0%) | 0% | 33.4 | 153,502 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 40.04 per share. | 02 Jul 2021 | 7,810 | 1,775,684 (4%) | 0% | 40.0 | 312,712 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 40.05 per share. | 28 Jun 2021 | 22,826 | 1,783,494 (4%) | 0% | 40.0 | 914,181 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 40.04 per share. | 28 Jun 2021 | 14,663 | 1,806,320 (4%) | 0% | 40.0 | 587,107 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.53 per share. | 15 Jun 2021 | 12,200 | 865,809 (2%) | 0% | 34.5 | 421,266 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 33.80 per share. | 15 Jun 2021 | 17,800 | 878,009 (2%) | 0% | 33.8 | 601,640 | Common Stock |
| Tanya Lewis | Chief Dev. Oper. Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 110,000 | 110,000 | - | - | Employee Stock Option (right to buy) | |
| Tanya Lewis | Chief Dev. Oper. Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 73,333 | 73,333 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2021 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Sushil Patel | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2021 | 88,333 | 88,333 (0%) | 0% | 0 | Common Stock | |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.98 per share. | 15 Apr 2021 | 2,700 | 895,809 (2%) | 0% | 30.0 | 80,946 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.69 per share. | 15 Apr 2021 | 27,300 | 898,509 (2%) | 0% | 30.7 | 837,837 | Common Stock |
| Hyam I. Levitsky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Paolo Pucci | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Tanya Lewis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Kapil Dhingra | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 85,415 | 1,340,712 (3%) | 0% | 0 | Common Stock | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 128,125 | 128,125 | - | - | Employee Stock Option (right to buy) | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 46,035 | 46,035 (0%) | 0% | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 69,050 | 69,050 | - | - | Employee Stock Option (right to buy) | |
| Dieter Weinand | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 24,750 | 24,750 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 34,165 | 210,159 (0%) | 0% | 0 | Common Stock | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 51,250 | 51,250 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 76,865 | 1,820,983 (4%) | 0% | 0 | Common Stock | |
| Robert Coffin | Director, President & Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 115,300 | 115,300 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 39,285 | 925,809 (2%) | 0% | 0 | Common Stock | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 58,925 | 58,925 | - | - | Employee Stock Option (right to buy) | |
| Andrea Pirzkall | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 20,500 | 21,500 (0%) | 0% | 0 | Common Stock | |
| Andrea Pirzkall | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 30,750 | 30,750 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 33.22 per share. | 15 Mar 2021 | 18,518 | 886,624 (2%) | 0% | 33.2 | 615,168 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 32.67 per share. | 15 Mar 2021 | 100 | 886,524 (2%) | 0% | 32.7 | 3,267 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.06 per share. | 15 Mar 2021 | 11,382 | 905,142 (2%) | 0% | 34.1 | 387,671 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 35.84 per share. | 16 Feb 2021 | 11,380 | 916,524 (2%) | 0% | 35.8 | 407,859 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 36.61 per share. | 16 Feb 2021 | 18,620 | 927,904 (2%) | 0% | 36.6 | 681,678 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.14 per share. | 26 Jan 2021 | 5,558 | 946,000 (2%) | 0% | 46.1 | 256,446 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 44.87 per share. | 22 Jan 2021 | 30,197 | 1,773,921 (4%) | 0% | 44.9 | 1,354,939 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 43.99 per share. | 22 Jan 2021 | 29,803 | 1,744,118 (4%) | 0% | 44.0 | 1,311,034 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.78 per share. | 14 Jan 2021 | 17,452 | 1,287,845 (3%) | 0% | 44.8 | 781,501 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.40 per share. | 14 Jan 2021 | 7,632 | 1,255,297 (3%) | 0% | 42.4 | 323,597 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.15 per share. | 14 Jan 2021 | 800 | 1,262,929 (3%) | 0% | 43.2 | 34,520 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.02 per share. | 14 Jan 2021 | 9,409 | 1,263,729 (3%) | 0% | 43.0 | 404,775 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.71 per share. | 14 Jan 2021 | 6,059 | 1,273,138 (3%) | 0% | 43.7 | 264,839 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.95 per share. | 14 Jan 2021 | 1,100 | 1,279,197 (3%) | 0% | 45.0 | 49,445 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.06 per share. | 14 Jan 2021 | 100 | 1,280,297 (3%) | 0% | 43.1 | 4,306 | Common Stock |
| Philip Astley-Sparke | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.61 per share. | 14 Jan 2021 | 7,448 | 1,280,397 (3%) | 0% | 43.6 | 324,807 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2021 | 20,000 | 108,203 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2021 | 29,273 | 78,930 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2021 | 5,727 | 73,203 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 14 Jan 2021 | 20,000 | 195,994 (0%) | 0% | 1.0 | 20,200 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 45.02 per share. | 14 Jan 2021 | 20,000 | 175,994 (0%) | 0% | 45.0 | 900,400 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 14 Jan 2021 | 29,273 | 205,267 (0%) | 0% | 1.0 | 29,566 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 43.58 per share. | 14 Jan 2021 | 29,273 | 175,994 (0%) | 0% | 43.6 | 1,275,717 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 14 Jan 2021 | 5,727 | 181,721 (0%) | 0% | 1.0 | 5,784 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 43.24 per share. | 14 Jan 2021 | 600 | 181,121 (0%) | 0% | 43.2 | 25,944 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 42.38 per share. | 14 Jan 2021 | 5,127 | 175,994 (0%) | 0% | 42.4 | 217,282 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 13 Jan 2021 | 100 | 0 (0%) | 0% | 44.2 | 4,419 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2021 | 14,900 | 140,000 | - | - | Employee Stock Option (right to buy) | |
| Jean M. Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jan 2021 | 100 | 154,900 | - | - | Employee Stock Option (right to buy) | |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 13 Jan 2021 | 600 | 0 (0%) | 0% | 44 | 26,400 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.55 per share. | 13 Jan 2021 | 14,300 | 600 (0%) | 0% | 44.6 | 637,065 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 13 Jan 2021 | 14,900 | 14,900 (0%) | 0% | 14.1 | 209,792 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 13 Jan 2021 | 100 | 100 (0%) | 0% | 14.1 | 1,408 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2020 | 50,704 | 32,758 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.75 per share. | 23 Dec 2020 | 50,704 | 175,994 (0%) | 0% | 1.8 | 88,732 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 40.04 per share. | 22 Dec 2020 | 220,000 | 1,804,118 (4%) | 0% | 40.0 | 8,808,800 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 41.95 per share. | 18 Dec 2020 | 1,042 | 951,558 (2%) | 0% | 42.0 | 43,712 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 41.95 per share. | 18 Dec 2020 | 265 | 19,285 (0%) | 0% | 42.0 | 11,117 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 41.95 per share. | 18 Dec 2020 | 3,012 | 2,263,627 (6%) | 0% | 41.9 | 126,353 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.40 per share. | 15 Dec 2020 | 9,710 | 958,589 (2%) | 0% | 42.4 | 411,704 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.12 per share. | 15 Dec 2020 | 120 | 958,469 (2%) | 0% | 43.1 | 5,174 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.08 per share. | 15 Dec 2020 | 24 | 958,445 (2%) | 0% | 44.1 | 1,058 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.09 per share. | 15 Dec 2020 | 70 | 2,283,541 (6%) | 0% | 44.1 | 3,086 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.12 per share. | 15 Dec 2020 | 349 | 2,283,611 (6%) | 0% | 43.1 | 15,049 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.40 per share. | 15 Dec 2020 | 2,432 | 21,049 (0%) | 0% | 42.4 | 103,117 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.13 per share. | 15 Dec 2020 | 30 | 21,019 (0%) | 0% | 43.1 | 1,294 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 15 Dec 2020 | 6 | 21,013 (0%) | 0% | 44 | 264 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.13 per share. | 15 Dec 2020 | 8,849 | 2,274,692 (6%) | 0% | 42.1 | 372,808 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.13 per share. | 15 Dec 2020 | 3,060 | 955,385 (2%) | 0% | 42.1 | 128,918 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.13 per share. | 15 Dec 2020 | 766 | 20,247 (0%) | 0% | 42.1 | 32,272 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.00 per share. | 15 Dec 2020 | 8,053 | 2,266,639 (6%) | 0% | 42 | 338,226 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.00 per share. | 15 Dec 2020 | 2,785 | 952,600 (2%) | 0% | 42 | 116,970 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.00 per share. | 15 Dec 2020 | 697 | 19,550 (0%) | 0% | 42 | 29,274 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.40 per share. | 15 Dec 2020 | 28,078 | 2,283,960 (6%) | 0% | 42.4 | 1,190,507 | Common Stock |
| Jean Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.09 per share. | 14 Dec 2020 | 389 | 0 (0%) | 0% | 42.1 | 16,373 | Common Stock |
| Jean Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 25,000 | 155,000 | - | - | Employee Stock Option (right to buy) | |
| Jean Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.86 per share. | 14 Dec 2020 | 6,755 | 389 (0%) | 0% | 42.9 | 289,519 | Common Stock |
| Jean Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 43.70 per share. | 14 Dec 2020 | 17,856 | 7,144 (0%) | 0% | 43.7 | 780,307 | Common Stock |
| Jean Franchi | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.08 per share. | 14 Dec 2020 | 25,000 | 25,000 (0%) | 0% | 14.1 | 352,000 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 11 Dec 2020 | 12,590 | 125,290 (0%) | 0% | 3.3 | 41,547 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2020 | 12,590 | 121,691 | - | - | Employee Stock Option (right to buy) | |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.06 per share. | 10 Dec 2020 | 181 | 23,481 (0%) | 0% | 44.1 | 7,975 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.54 per share. | 10 Dec 2020 | 1,855 | 23,662 (0%) | 0% | 43.5 | 80,767 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.69 per share. | 10 Dec 2020 | 240 | 25,517 (0%) | 0% | 42.7 | 10,246 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.06 per share. | 10 Dec 2020 | 722 | 968,299 (2%) | 0% | 44.1 | 31,811 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.54 per share. | 10 Dec 2020 | 7,409 | 969,021 (2%) | 0% | 43.5 | 322,588 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.69 per share. | 10 Dec 2020 | 961 | 976,430 (2%) | 0% | 42.7 | 41,025 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.06 per share. | 10 Dec 2020 | 2,087 | 2,312,038 (6%) | 0% | 44.1 | 91,953 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.92 per share. | 10 Dec 2020 | 205 | 25,757 (0%) | 0% | 43.9 | 9,004 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.69 per share. | 10 Dec 2020 | 2,776 | 2,335,553 (6%) | 0% | 42.7 | 118,507 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.68 per share. | 10 Dec 2020 | 1,099 | 28,649 (0%) | 0% | 42.7 | 46,905 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.35 per share. | 10 Dec 2020 | 917 | 985,029 (2%) | 0% | 44.4 | 40,669 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.48 per share. | 10 Dec 2020 | 2,996 | 985,946 (2%) | 0% | 43.5 | 130,266 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.68 per share. | 10 Dec 2020 | 4,389 | 988,942 (2%) | 0% | 42.7 | 187,323 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.35 per share. | 10 Dec 2020 | 2,653 | 2,360,415 (6%) | 0% | 44.4 | 117,661 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.48 per share. | 10 Dec 2020 | 8,666 | 2,363,068 (6%) | 0% | 43.5 | 376,798 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.68 per share. | 10 Dec 2020 | 12,691 | 2,371,734 (6%) | 0% | 42.7 | 541,652 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.54 per share. | 10 Dec 2020 | 21,428 | 2,314,125 (6%) | 0% | 43.5 | 932,975 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Dec 2020 | 1,707 | 25,962 (0%) | 0% | 43.3 | 73,947 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.92 per share. | 10 Dec 2020 | 821 | 977,391 (2%) | 0% | 43.9 | 36,058 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Dec 2020 | 6,817 | 978,212 (2%) | 0% | 43.3 | 295,312 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.92 per share. | 10 Dec 2020 | 2,374 | 2,338,329 (6%) | 0% | 43.9 | 104,266 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Dec 2020 | 19,712 | 2,340,703 (6%) | 0% | 43.3 | 853,924 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.35 per share. | 10 Dec 2020 | 230 | 27,669 (0%) | 0% | 44.4 | 10,201 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.48 per share. | 10 Dec 2020 | 750 | 27,899 (0%) | 0% | 43.5 | 32,610 | Common Stock |
| Joseph P. Slattery | Director | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 08 Dec 2020 | 5,200 | 6,667 (0%) | 0% | 46 | 239,200 | Common stock |
| Joseph P. Slattery | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Dec 2020 | 5,200 | 24,640 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 08 Dec 2020 | 5,200 | 11,867 (0%) | 0% | 3.3 | 17,160 | Common Stock |
| Kapil Dhingra | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2020 | 40,000 | 3,169 | - | - | Stock Option (right to buy) | |
| Kapil Dhingra | Director | Sale of securities on an exchange or to another person at price $ 45.09 per share. | 07 Dec 2020 | 24,675 | 15,325 (0%) | 0% | 45.1 | 1,112,596 | Common Stock |
| Kapil Dhingra | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.75 per share. | 07 Dec 2020 | 40,000 | 40,000 (0%) | 0% | 1.8 | 70,000 | Common Stock |
| Kapil Dhingra | Director | Sale of securities on an exchange or to another person at price $ 46.22 per share. | 07 Dec 2020 | 13,523 | 1,802 (0%) | 0% | 46.2 | 625,033 | Common Stock |
| Kapil Dhingra | Director | Sale of securities on an exchange or to another person at price $ 47.04 per share. | 07 Dec 2020 | 1,802 | 0 (0%) | 0% | 47.0 | 84,766 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.32 per share. | 07 Dec 2020 | 1,747 | 2,384,425 (6%) | 0% | 45.3 | 79,174 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.46 per share. | 07 Dec 2020 | 8,636 | 2,477,660 (6%) | 0% | 45.5 | 392,593 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.97 per share. | 07 Dec 2020 | 23,174 | 2,454,486 (6%) | 0% | 46.0 | 1,065,309 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.91 per share. | 07 Dec 2020 | 1,222 | 2,453,264 (6%) | 0% | 46.9 | 57,324 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.45 per share. | 07 Dec 2020 | 2,962 | 1,097,038 (2%) | 0% | 45.5 | 134,623 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.06 per share. | 07 Dec 2020 | 26,713 | 1,070,325 (2%) | 0% | 46.1 | 1,230,401 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.93 per share. | 07 Dec 2020 | 2,322 | 1,068,003 (2%) | 0% | 46.9 | 108,971 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.46 per share. | 07 Dec 2020 | 748 | 37,822 (0%) | 0% | 45.5 | 34,004 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.97 per share. | 07 Dec 2020 | 2,007 | 35,815 (0%) | 0% | 46.0 | 92,262 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.91 per share. | 07 Dec 2020 | 106 | 35,709 (0%) | 0% | 46.9 | 4,972 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.02 per share. | 07 Dec 2020 | 7,001 | 2,446,263 (6%) | 0% | 46.0 | 322,186 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.94 per share. | 07 Dec 2020 | 33,133 | 2,413,130 (6%) | 0% | 46.9 | 1,555,263 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.14 per share. | 07 Dec 2020 | 19,620 | 1,048,383 (2%) | 0% | 46.1 | 905,267 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.89 per share. | 07 Dec 2020 | 45,027 | 1,003,356 (2%) | 0% | 46.9 | 2,111,316 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.02 per share. | 07 Dec 2020 | 606 | 35,103 (0%) | 0% | 46.0 | 27,888 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.94 per share. | 07 Dec 2020 | 2,869 | 32,234 (0%) | 0% | 46.9 | 134,671 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.51 per share. | 07 Dec 2020 | 1,745 | 2,411,385 (6%) | 0% | 42.5 | 74,180 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.36 per share. | 07 Dec 2020 | 17,883 | 2,393,502 (6%) | 0% | 43.4 | 775,407 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.69 per share. | 07 Dec 2020 | 7,330 | 2,386,172 (6%) | 0% | 44.7 | 327,578 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.51 per share. | 07 Dec 2020 | 603 | 1,002,753 (2%) | 0% | 42.5 | 25,634 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.36 per share. | 07 Dec 2020 | 6,183 | 996,570 (2%) | 0% | 43.4 | 268,095 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.69 per share. | 07 Dec 2020 | 2,535 | 994,035 (2%) | 0% | 44.7 | 113,289 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.32 per share. | 07 Dec 2020 | 604 | 993,431 (2%) | 0% | 45.3 | 27,373 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 46.47 per share. | 07 Dec 2020 | 100 | 993,331 (2%) | 0% | 46.5 | 4,647 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 42.51 per share. | 07 Dec 2020 | 151 | 32,083 (0%) | 0% | 42.5 | 6,419 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 43.36 per share. | 07 Dec 2020 | 1,549 | 30,534 (0%) | 0% | 43.4 | 67,165 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 44.69 per share. | 07 Dec 2020 | 635 | 29,899 (0%) | 0% | 44.7 | 28,378 | Common Stock |
| Jason P. Rhodes | Director | Sale of securities on an exchange or to another person at price $ 45.32 per share. | 07 Dec 2020 | 151 | 29,748 (0%) | 0% | 45.3 | 6,843 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 44.41 per share. | 16 Nov 2020 | 3,759 | 1,006,524 (2%) | 0% | 44.4 | 166,937 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 45.04 per share. | 16 Nov 2020 | 10,941 | 1,010,283 (2%) | 0% | 45.0 | 492,783 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 46.43 per share. | 16 Nov 2020 | 300 | 1,021,224 (2%) | 0% | 46.4 | 13,929 | Common Stock |
| Tanya Lewis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Nov 2020 | 33,000 | 33,000 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 30.15 per share. | 14 Oct 2020 | 7,000 | 121,700 (0%) | 0% | 30.2 | 211,050 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2020 | 16,000 | 128,203 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 35.04 per share. | 14 Oct 2020 | 9,000 | 112,700 (0%) | 0% | 35.0 | 315,360 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 14 Oct 2020 | 16,000 | 128,700 (0%) | 0% | 1.0 | 16,160 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 24.11 per share. | 15 Sep 2020 | 10,271 | 1,023,053 (2%) | 0% | 24.1 | 247,634 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 24.83 per share. | 15 Sep 2020 | 1,529 | 1,021,524 (2%) | 0% | 24.8 | 37,965 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 23.09 per share. | 15 Sep 2020 | 3,200 | 1,033,324 (2%) | 0% | 23.1 | 73,888 | Common Stock |
| Pamela Esposito | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.05 per share. | 31 Aug 2020 | 5,000 | 112,700 (0%) | 0% | 27.1 | 135,250 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2020 | 5,000 | 144,203 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 31 Aug 2020 | 5,000 | 117,700 (0%) | 0% | 1.0 | 5,050 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 23.19 per share. | 17 Aug 2020 | 5,964 | 1,036,524 (2%) | 0% | 23.2 | 138,305 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 23.60 per share. | 17 Aug 2020 | 9,036 | 1,042,488 (2%) | 0% | 23.6 | 213,250 | Common Stock |
| Andrea Pirzkall | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jul 2020 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 21.02 per share. | 09 Jul 2020 | 24,250 | 2,024,118 (5%) | 0% | 21.0 | 509,735 | Common Stock |
| Robert Coffin | Director, President & Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 22.32 per share. | 09 Jul 2020 | 145,500 | 2,048,368 (5%) | 0% | 22.3 | 3,247,560 | Common Stock |
| Hyam I. Levitsky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 24,249 | 24,249 | - | - | Stock Option (right to buy) | |
| Paolo Pucci | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 33,000 | 33,000 | - | - | Stock Option (right to buy) | |
| Kapil Dhingra | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Jason P. Rhodes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 16,500 | 16,500 | - | - | Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 265,000 | 265,000 | - | - | Employee Stock Option (right to buy) | |
| Jean Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 56,350 | 56,350 | - | - | Employee Stock Option (right to buy) | |
| Dieter Weinand | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 24,750 | 24,750 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 85,450 | 85,450 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, Pres & Chief Res & Dev Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 265,000 | 265,000 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 116,550 | 116,550 | - | - | Employee Stock Option (right to buy) | |
| Stephen A. Gorgol | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2020 | 66,050 | 66,050 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, Pres & Chief Res & Dev Officer | Sale of securities on an exchange or to another person at price $ 17.04 per share. | 20 Feb 2020 | 24,250 | 2,193,868 (5%) | 0% | 17.0 | 413,220 | Common Stock |
| Robert Coffin | Director, Pres & Chief Res & Dev Officer | Sale of securities on an exchange or to another person at price $ 17.03 per share. | 12 Feb 2020 | 24,250 | 2,218,118 (6%) | 0% | 17.0 | 412,978 | Common Stock |
| Robert Coffin | Director, Pres & Chief Res & Dev Officer | Sale of securities on an exchange or to another person at price $ 17.04 per share. | 12 Feb 2020 | 24,250 | 2,242,368 (6%) | 0% | 17.0 | 413,220 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2019 | 25,700 | 83,462 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.75 per share. | 20 Dec 2019 | 25,700 | 112,700 (0%) | 0% | 1.8 | 44,975 | Common Stock |
| Jean Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2019 | 180,000 | 180,000 | - | - | Employee Stock Option (right to buy) | |
| Howard Kaufman | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2019 | 58,067 | 91,135 | - | - | Employee Stock Option (right to buy) | |
| Howard Kaufman | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.30 per share. | 26 Nov 2019 | 58,067 | 58,067 (0%) | 0% | 3.3 | 191,621 | Common Stock |
| Jason P. Rhodes | None | Purchase of securities on an exchange or from another person at price $ 13.61 per share. | 18 Nov 2019 | 1,100,000 | 1,100,000 (3%) | 3% | 13.6 | 14,971,000 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 06 Nov 2019 | 14,500 | 1,355,297 (3%) | 0% | 17 | 246,500 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.02 per share. | 06 Nov 2019 | 14,500 | 1,369,797 (3%) | 0% | 17.0 | 246,790 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 06 Nov 2019 | 24,250 | 2,266,618 (6%) | 0% | 17 | 412,250 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.02 per share. | 06 Nov 2019 | 24,250 | 2,290,868 (6%) | 0% | 17.0 | 412,735 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 06 Nov 2019 | 11,250 | 1,051,524 (2%) | 0% | 17 | 191,250 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.02 per share. | 06 Nov 2019 | 11,250 | 1,062,774 (2%) | 0% | 17.0 | 191,475 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 04 Nov 2019 | 14,500 | 1,384,297 (3%) | 0% | 17 | 246,500 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 04 Nov 2019 | 14,500 | 1,398,797 (3%) | 0% | 17.1 | 247,254 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 04 Nov 2019 | 24,250 | 2,315,118 (6%) | 0% | 17 | 412,250 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 04 Nov 2019 | 24,250 | 2,339,368 (6%) | 0% | 17.1 | 413,511 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 04 Nov 2019 | 11,250 | 1,085,274 (2%) | 0% | 17.1 | 191,835 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 04 Nov 2019 | 11,250 | 1,074,024 (2%) | 0% | 17 | 191,250 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 31 Oct 2019 | 14,500 | 1,413,297 (3%) | 0% | 17 | 246,500 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 31 Oct 2019 | 24,250 | 2,363,618 (6%) | 0% | 17 | 412,250 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 31 Oct 2019 | 11,250 | 1,096,524 (2%) | 0% | 17 | 191,250 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 23 Sep 2019 | 14,500 | 1,427,797 (3%) | 0% | 17.1 | 247,225 | Common Stock |
| Robert Coffin | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 23 Sep 2019 | 24,250 | 2,387,868 (6%) | 0% | 17.1 | 413,463 | Common Stock |
| Colin Love | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.05 per share. | 23 Sep 2019 | 11,250 | 1,107,774 (3%) | 0% | 17.1 | 191,813 | Common Stock |
| Hyam I. Levitsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Kapil Dhingra | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Jason P. Rhodes | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Philip Astley-Sparke | Director, Executive Chairman | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 153,050 | 153,050 | - | - | Employee Stock Option (right to buy) | |
| Dieter Weinand | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 75,750 | 75,750 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President and C.E.O. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 219,300 | 219,300 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 78,900 | 78,900 | - | - | Employee Stock Option (right to buy) | |
| Howard Kaufman | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 80,500 | 80,500 | - | - | Employee Stock Option (right to buy) | |
| Stephen A. Gorgol | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2019 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.75 per share. | 13 Dec 2018 | 87,000 | 87,000 (0%) | 0% | 1.8 | 152,250 | Common Stock |
| Pamela Esposito | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2018 | 87,000 | 109,162 | - | - | Employee Stock Option (right to buy) | |
| Hyam I. Levitsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Joseph P. Slattery | None | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 24 Jul 2018 | 6,667 | 6,667 (0%) | 0% | 15 | 100,005 | Common Stock |
| Kapil Dhingra | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Jason P. Rhodes | None | 24 Jul 2018 | 1,013,547 | 4,453,386 (14%) | 3% | 0 | Common Stock | ||
| Jason P. Rhodes | None | 24 Jul 2018 | 3,439,839 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Jason P. Rhodes | None | 24 Jul 2018 | 1,013,547 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Jason P. Rhodes | None | 24 Jul 2018 | 3,439,839 | 3,439,839 (11%) | 11% | 0 | Common Stock | ||
| Jason P. Rhodes | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 994,688 | 0 | - | - | Series Seed Convertible Preferred Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 248,672 | 248,672 | - | - | Warrant (right to buy) | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 248,672 | 0 | - | - | Warrant (right to buy) | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 2,579,881 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 1,013,547 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 13,500 | 13,500 | - | - | Stock Option (right to buy) | |
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 994,688 | 994,688 (3%) | 3% | 0 | Common Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 2,579,881 | 3,574,569 (11%) | 8% | 0 | Common Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | 24 Jul 2018 | 1,013,547 | 4,588,116 (14%) | 3% | 0 | Common Stock | ||
| Sander Slootweg | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 24 Jul 2018 | 133,333 | 4,721,449 (15%) | 0% | 15 | 1,999,995 | Common Stock |
| Philip Astley-Sparke | Director, Executive Chairman | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 140,000 | 140,000 | - | - | Employee Stock Option (right to buy) | |
| Dieter Weinand | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 27,000 | 27,000 | - | - | Stock Option (right to buy) | |
| Pamela Esposito | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 70,000 | 70,000 | - | - | Employee Stock Option (right to buy) | |
| Robert Coffin | Director, President and C.E.O. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 175,000 | 175,000 | - | - | Employee Stock Option (right to buy) | |
| Colin Love | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Howard Kaufman | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Stephen A. Gorgol | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2018 | 35,000 | 35,000 | - | - | Employee Stock Option (right to buy) |